Séverine Rangama

University of Warwick

Project

Investigating the impact of hospital effluent on the spread of antimicrobial resistance in the environment

Supervisors

Professor E.M.H Wellington (School of Life Sciences, University of Warwick), Professor Peter Hawkey (Institute of Microbiology and Infection, Biosciences, University of Birmingham), Dr Jennifer Holden (School of Life Sciences, University of Warwick)

PhD Summary

The discovery of antibiotics in the 20th century revoluzioned modern medicine. However, their widespread and persistent use as both prophylaxis and therapeutics has resulted in the emergence of antimicrobial resistance (AMR) across numerous bacteria genera. Antibiotic agents enter the environment via a variety of anthropogenic sources including wastewater treatment plants and agricultural runoff . There are still significant uncertainties about the whole waste treatment process particularly surrounding human and animal faeces where the gut microbial resistome may be significant. The aim of this PhD is to further elucidate dissemination pathways for antimicrobial resistance genes (ARGs) via waste water treatment plants, hospital and animal waste. An evaluation of the impact of hospital effluent on the supply of ARGs to the waste water treatment plant and evaluate the efficiency of waste water treatment plant in reducing the antimicrobial resistance load will be done. In addition, further investigation will be carried out to determine the contribution of animal manure to environmental reservoirs of ARG and whether anaerobic digestion can mitigate the spread of resistance to the environment.

Previous Activity

I did my Master’s in Structural and Functional Biochemistry at the University Lyon 1 in France. During the last year of my master’s program, I did an internship for nine months. The aim of the project was the development of a method to detect and measure the concentration of glyphosate, a highly effective broad-spectrum, non-selective herbicide in water samples.

Why did you choose Docotoral Research?

Following my masters, my continued interest in theory and application led me to want to pursue a PhD. This could be a way to strengthen my knowledge and acquire new skills and technique. The Doctoral Research would also allow me to build an experienced professional network, to collaborate and exchange ideas within a team, which is necessary for the future.

Why did you choose a CENTA Studentship?

The Centa studentship provides different training which I think will help me develop as a good scientist. Moreover by doing my PhD outside of a French-speaking country, I have the opportunity to be immersed in a new environment and will get to see how scientific information is developed from another prospective